Strain Information | |
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Image | |
BRC No. | RBRC01445 |
Type | Spontaneous Mutation |
Species | Mus musculus |
Strain name | DDY-Dao<G181R>/ConnRbrc |
Former Common name | ddY/DAO<-> mice |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | albino [c/c] |
Strain development | Spontaneous mutation arose in the ddY closed colony. Developed by Dr. Ryuichi Konno, Dokkyo University. |
Strain description | This mutant mice have a missense mutation (Gly181Arg) in DAO gene. The mice with this mutant allele lack the D-amino acid oxidase activity. The levels of D-serine in the cerebellum and rostral brain of mutant mice are higher than those of normal (Dao1+/+) mice. The mutant mice display a decrease of stereotypy and ataxia induced by NMDA receptor antagonists. This strain is useful for study of schizophrenia. |
Colony maintenance | Sibling Mating (Homozygote x Homozygote)Homozygous mutant mice are viable and fertile. |
References | J. Chromatogr. B, 757, 119-125 (2001). 11419736 Am. J. Physiol., 265, G699-G703 (1993). 7901999 Biochim. Biophys. Acta., 1139, 315-318 (1992). 1355365 Lab. Anim. Sci., 38, 292-295 (1988). 2900911 Neurosci. Lett., 297, 25-28 (2001). 11114476 Synapse, 50, 130-136 (2003). 12923815 Arch Toxicol., 74, 473-479 (2000). 11097385 Anal. Biochem., 298, 253-258 (2001). 11700980 Genetics, 103, 277-285 (1983). 6131852 Int. J. Biochem., 23, 1301-1305 (1991). 1686595 Biochim. Biophys. Acta., 1335, 173-181 (1997). 9133654 Brain Res., 1033, 210-215 (2005). 15694926 Biochim. Biophys. Acta., 967, 382-390 (1988). 2904279 Metabolism, 37, 1139-1142 (1988). 2904113 Amino Acids, 10, 133-143 (1996). 24178475 Am. J. Physiol. Endocrinol. Metab., 287, E160-E165 (2004). 15026304 J. Nutr., 114, 1617-1621 (1984). 6147398 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter |
Ordering Information | |
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Donor DNA | |
Research application | Cell Biology Research Genetics Research Neurobiology Research Toxicology Research |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT agrees to include the DEPOSITOR/DEVELOPER as a co-author in any publications resulted by the use of the BIOLOGICAL RESOURCE during the first 2 years after deposition by the DEPOSITOR to the RIKEN BRC. |
Depositor | Ryuichi, Konno (Dokkyo Medical University) |
Strain Status | Frozen embryos |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |