Strain Data Sheet
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Data update: Jul 7, 2014
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RBRC No. RBRC00109  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name C3H/HeN-TgH(Zic1)  
Former Common name Zic1 KO (C3H background)  
H-2 Haplotype No Data  
ES cell line J1 [129/Sv](D3 subline)  
Donor strain B6;129S4-Zic1tm1Jaru  
Background strain C3H/HeN  
Appearance
 1 Appearance agouti  
Genotype No Data  
Strain development Developed by Dr. Jun Aruga. Protein coding region of Zic1 exon1 is replaced by PGK-neo gene homologous recombination in ES cell. This strain has been introduced into C3H/HeN genetic background by successive backcrossing for more than 10 generations.  
Strain description The Zic1 gene is known to have important roles in the cerebellar function. In this strain protein coding region of Zic! exon 1 was replaced by PGK-Neo gene by homologous recombination in J1 ES cells.
Genotype of Affected Mutation:Zic1 null heterozygous.  
Colony maintenance Backcrossing to C3H/HeN. Or sister-brother mating of heterozygotes. Breeding performance is good. The mice are provided as heterozygous breeder pairs.  
Health Certificate No Data  
Gene Details
Promoter No Data  
 1 Symbol Zic1  
Symbol name zinc finger protein of the cerebellum 1  
Chromosome 9  
Common name zinc finger protein of the cerebellum 1  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 9  
Common name neo; neomycin;  
Symbol description No Data  
References Brain Res Mol Brain Res. 2000 May 31;78(1-2):15-25.
Dev Biol. 2002 Apr 15;244(2):329-41.
J Neurosci. 1998 Jan 1;18(1):284-93.
Mech Dev. 1999 Dec;89(1-2):141-50.  
A 5' segment of the mouse Zic1 gene contains a region specific enhancer for dorsal hindbrain and spinal cord.
A 5' segment of the mouse Zic1 gene contains a region specific enhancer for dorsal hindbrain and spinal cord.
A 5' segment of the mouse Zic1 gene contains a region specific enhancer for dorsal hindbrain and spinal cord.
A 5' segment of the mouse Zic1 gene contains a region specific enhancer for dorsal hindbrain and spinal cord.
Research applications Analysis of abnormal behavior,
Analysis of cerebellar development,
Developmental Biology Research,
It can be regarded as a model of human Joubert Syndrome. ogura et al. Behav. Genet. 31, 317-324 (2001).,
Mouse Models for Human Disease,
Neurobiology Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Neurosci., 18, 284-293 (1998).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.  
Additional information
 1 Lab HP  
Depositor Aruga, Jun (RIKEN Brain Science Institute)  Aruga, Jun 
Strain Status /
Availability
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