Strain Information | |
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Image | |
BRC No. | RBRC00193 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | GRS.Cg-Tnc<tm1Sia>/Rbrc |
Former Common name | GRS/A-TgH(Tnc), GR-TNKO |
H-2 Haplotype | |
ES Cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] |
Background strain | GRS/A |
Appearance | albino [a/a, c/c] |
Strain development | The original tenascin deficient mice with mixed genetic background was reported to develop normally without tenascin. To clarify the biological function of tenascin-C in vivo, several congenic strains with inbred background have been developed by Dr. Kusakabe M, Cell Biology Laboratory, Life Science Tsukuba Research Center, RIKEN since 1992.The tenascin-deficient congenic strains were thus developed by successive backcrossing into A, BALB/cA, C57BL/6N, C3H/HeN, and GRS/A. |
Strain description | This strain is useful to study the biological function of extracellular matrix tenascin-C in vivo, espacially in the field of tumor development, tumor metastasis, wound healing, tissue regeneration, angiogenesis, tissue interaction etc. Background strain, GRS/A have a high incidence of mammary tumours which are highly hormone-responsive in breeding females. |
Colony maintenance | |
References | Genes Dev., 6, 1821-1831 (1992). 1383086 Invest. Ophthalmol. Visual. Sci., 40, 1071-1080 (1999). 10235540 Am. J. Pathol., 152, 1237-1245 (1998). 9588892 J. Neurosci., 15, 1971-1983 (1995). 7534342 Gene, 104, 177-185 (1991). 1717349 Biochem. Biophys. Res. Commun., 231, 356-359 (1997). 9070278 Exp. Mol. Pathol., 72, 186-195 (2002). 12009782 Biochem. Biophys. Res. Commun., 290, 1220-1227 (2002). 11811993 Biochem. Biophys. Res. Commun., 221, 151-156 (1996). 8660327 J. Invest. Dermatol., 111, 930-935 (1998). 9856798 Perspect. Dev. Neurobiol., 2, 111-116 (1994). 7530137 J. Comp. Neurol., 430, 485-500 (2001). 11169482 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Tnctenascin C4Tnc<tm1Sia>targeted mutation 1, Shinichi AizawaTnc; tenascin C, Hxb, Ten, TN-C, AI528729 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter lacZbeta-galactosidase (E. coli)4 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)4neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter) |
Ordering Information | |
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Donor DNA | E. coli lacZ, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse tenascin genomic DNA |
Research application | |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Am. J. Pathol., 152, 1237-1245 (1998). J. Invest. Dermatol., 111, 930-935 (1998). Invest. Ophthalmol. Visual. Sci., 40, 1071-1080 (1999). |
Depositor | RIKEN BRC (RIKEN BRC) |
Strain Status | Frozen embryos |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |