Strain Data Sheet

RBRC00300

Strain Information

Image
BRC No.RBRC00300
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S6-Rela<tm1Yuo>/1Rbrc
Former Common nameRelA KO, RKO-1
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strainC57BL/6JJcl
Appearanceblack
Strain development
Strain description
Colony maintenance
ReferencesProc. Natl. Acad. Sci. USA, 96, 2994-2999 (1999). 10077625
J. Exp. Med., 185, 953-961 (1997). 9120401

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)19Rela<tm1Yuo>targeted mutation 1, Yuichi Obatap65 NFkB, p65 NF-kappa B, avian reticuloendotheliosis viral (v-rel) oncogene homolog A

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)19neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Ordering Information

Donor DNAherpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse RelA genomic DNA
Research applicationCell Biology Research
Immunology and Inflammation Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J Exp Med., 185, 953-961 (1997). Any patent rights and other intellectual properties are retained by the depositor. Users should contact the depositor in the case of application for any patents with the results from these mice.
DepositorTakahiro Doi (RIKEN)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

Mise-Omata S, Kuroda E, Niikura J, Yamashita U, Obata Y, Doi TS.
A proximal kappaB site in the IL-23 p19 promoter is responsible for RelA- and c-Rel-dependent transcription.
J Immunol 179(10) 6596-603(2007) 17982049

Kawauchi K, Araki K, Tobiume K, Tanaka N.
p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation.
Nat Cell Biol 10(5) 611-8(2008) 18391940