|
RBRC No. |
RBRC00357
|
|
Type |
Targeted Mutation |
 |
|
Species |
Mus musculus |
|
Strain name |
BALB/cA-TgH(Tnc)-Foxn1nu |
|
Former Common name |
BALB/cA-Tnc-nude |
|
H-2 Haplotype |
No Data |
|
Background strain |
BALB/cA |
|
Appearance |
| 1 |
Appearance |
No Data |
| Genotype |
No Data |
|
Strain development |
Developed by Dr. M. Kusakabe, Tsukuba Life Science Center, Institute of Physical and Chemical Research (RIKEN). |
|
Strain description |
C.Cg-Tnc<tm1Sia> Foxn1<nu>. Mice lacking tenascin C gene with a nude mutation. This strain is useful for studying the function of tenascin C in tumor proliferation and metastasis, neoangiogenesis, interoganizartional interation, and transplantation of human tumor. |
|
Animal health report |
No Data |
|
Gene Details |
|
Promoter |
No Data |
| 1 |
Symbol |
Foxn1 |
| Symbol name |
forkhead box N1 |
| Chromosome |
11 |
| Common name |
D11Bhm185e, Hfh11, whn |
| Symbol description |
No Data |
| 2 |
Symbol |
Tnc |
| Symbol name |
tenascin C |
| Chromosome |
4 |
| Common name |
Tnc; tenascin C, Hxb, Ten, TN-C, AI528729 |
| Symbol description |
No Data |
| 3 |
Symbol |
lacZ |
| Symbol name |
beta-galactosidase (E. coli) |
| Chromosome |
4 |
| Common name |
No Data |
| Symbol description |
E. coli beta galactosidase |
|
Promoter |
mouse phosphoglycerate kinase promoter (PGK promoter) |
| 4 |
Symbol |
neo |
| Symbol name |
neomycin resistance gene (E. coli) |
| Chromosome |
4 |
| Common name |
neo; neomycin; |
| Symbol description |
No Data |
|
References |
Am J Pathol. 1998 May;152(5):1237-45.
Anticancer Res. 1998 Sep-Oct;18(5C):3817-91.
Biochem Biophys Res Commun. 1996 Apr 5;221(1):151-6.
Biochem Biophys Res Commun. 1997 Feb 13;231(2):356-9.
Biochem Biophys Res Commun. 2002 Feb 1;290(4):1220-7.
Exp Mol Pathol. 2002 Jun;72(3):186-95.
Gene. 1991 Aug 15;104(2):177-85.
Genes Dev. 1992 Oct;6(10):1821-31.
Invest Ophthalmol Vis Sci. 1999 May;40(6):1071-80.
J Comp Neurol. 2001 Feb 19;430(4):485-500.
J Invest Dermatol. 1998 Dec;111(6):930-5.
J Neurosci. 1995 Mar;15(3 Pt 1):1971-83.
|
|
Research applications |
No Data |
|
Specific Term and Conditions |
The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Am. J. Pathol., 152, 1237-1245 (1998). J. Invest. Dermatol., 111, 930-935 (1998). Invest. Ophthalmol. Visual. Sci., 40, 1071-1080 (1999). |
|
Additional information |
|
1 |
No Data |
|
2 |
Genotyping protocol <PCR> |
|
Depositor |
RIKEN, BioResource Center  |
|
Strain Status /
Availability
(Expected delivery) |
|
