Strain Information | |
---|---|
Image | |
BRC No. | RBRC00762 |
Type | Spontaneous Mutation |
Species | Mus musculus |
Strain name | C;B6-a/a-Tyrp1<b>-Kit<W-sh>/Rbrc |
Former Common name | W Sash Brown |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | white coat with black eyes [a/a b/b C/C sh/sh] |
Strain development | C57BL/6-Kit<W-sh> mice were deposited by Dr. Yukihiko Kitamuta, Osaka University to the RIKEN BRC. The mice were backcrossed to BALB/c for several generation, then maintained by sister-brother mating as homozygous state. |
Strain description | The Kit<W-sh> mutation arose spontaneously in the (C3H/HeN x 101/H)F1 at the MRC (Lyon et al., 1982). Homozygous mice are white coat with black eyes. Heterozygotes are black with a white sash. This strain is useful for study of melanogenesis and neural crest migration. |
Colony maintenance | Sibling mating (Homozygote x Homozygote)Homozygous mutant mice are viable and fertile. |
References | Blood, 83, 3509-3516 (1994). 7515715 Blood, 94, 2658-2666 (1999). 10515869 Blood, 15, 1448-1453 (1992) 1381627 Development, 118, 705-717 (1993). 7521281 Am. J. Pathol., 167, 835-848 (2005). 16127161 |
Health Report | |
---|---|
Examination Date / Room / Rack |
Gene | |
---|---|
Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter |
Ordering Information | |
---|---|
Donor DNA | |
Research application | Reproductive Biology Research |
Specific Term and Conditions | No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.) |
Depositor | RIKEN BRC (RIKEN BRC) |
Strain Status | Frozen embryos |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- Genetic Background |
BRC mice in Publications |
---|
Iino S, Horiguchi S, Horiguchi K, Hashimoto T. Interstitial cells of Cajal in Wsh/Wsh c-kit mutant mice. J Smooth Muscle Res 56(0) 58-68(2020) 33132281 Iino S, Horiguchi K, Nojyo Y. W(sh)/W(sh) c-Kit mutant mice possess interstitial cells of Cajal in the deep muscular plexus layer of the small intestine. Neurosci Lett 459(3) 123-6(2009) 19427361 |