Strain Data Sheet
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Data update: Feb 21, 2014
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RBRC No. RBRC00850  
Type Targeted Mutation CongenicCartagena  
Species Mus musculus  
Strain name B6.129P2-Itgaltm1Mak  
Former Common name C57BL/6-[KO]LFA-1; B6.129P2-Itgb2tm1Oci  
H-2 Haplotype No Data  
Donor strain 129P2/OlaHsd via E14 ES cell line  
Background strain No Data  
Appearance
 1 Appearance black  
Genotype No Data  
Strain development From Tak. W. Mak of ontario Cancer Institute, N6  
Strain description Original line was established by Tak Mak at Ontario Cancer Institute in Tronto (Schmits et al., J. Exp. Med., 183, 1415, 1996). Neo registance gene construct was introduced into the CD11a allele of an ES cell line E14k of 129/Ola origin. Mutant ES cells were injected to C57BL/6 blastocysts. Chimeras were mated with C57BL/6 and was backcrossed to C57BL/6 for 6 generations. After embryo transfer at Taconic, the colony has been maintained through intercrossing of homozygous mice.  
Health Certificate No Data  
Gene Details
Promoter No Data  
 1 Symbol Itgal  
Symbol name integrin alpha L  
Chromosome 7  
Common name CD11a, Integrin alpha L  
Symbol description No Data  
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 7  
Common name neo; neomycin;  
Symbol description No Data  
References J Exp Med. 1996 Apr 1;183(4):1415-26.  
LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor.
Research applications No Data  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.  
Additional information
 1 Lab HP  
Depositor Koyasu, Shigeo (Keio University)  Koyasu, Shigeo 
Strain Status /
Availability
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