|
RBRC No. |
RBRC00850
|
|
Type |
Targeted Mutation Congenic |
 |
|
Species |
Mus musculus |
|
Strain name |
B6.129P2-Itgaltm1Mak |
|
Former Common name |
C57BL/6-[KO]LFA-1; B6.129P2-Itgb2tm1Oci |
|
H-2 Haplotype |
No Data |
|
Donor strain |
129P2/OlaHsd via E14 ES cell line |
|
Background strain |
No Data |
|
Appearance |
| 1 |
Appearance |
black |
| Genotype |
No Data |
|
Strain development |
From Tak. W. Mak of ontario Cancer Institute, N6 |
|
Strain description |
Original line was established by Tak Mak at Ontario Cancer Institute in Tronto (Schmits et al., J. Exp. Med., 183, 1415, 1996). Neo registance gene construct was introduced into the CD11a allele of an ES cell line E14k of 129/Ola origin. Mutant ES cells were injected to C57BL/6 blastocysts. Chimeras were mated with C57BL/6 and was backcrossed to C57BL/6 for 6 generations. After embryo transfer at Taconic, the colony has been maintained through intercrossing of homozygous mice. |
|
Animal health report |
No Data |
|
Gene Details |
|
Promoter |
No Data |
| 1 |
Symbol |
Itgal |
| Symbol name |
integrin alpha L |
| Chromosome |
7 |
| Common name |
CD11a, Integrin alpha L |
| Symbol description |
No Data |
|
Promoter |
herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
| 2 |
Symbol |
neo |
| Symbol name |
neomycin resistance gene (E. coli) |
| Chromosome |
7 |
| Common name |
neo; neomycin; |
| Symbol description |
No Data |
|
References |
J Exp Med. 1996 Apr 1;183(4):1415-26. LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor. |
|
Research applications |
No Data |
|
Specific Term and Conditions |
The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. |
|
Additional information |
|
1 |
Lab HP |
|
Depositor |
Koyasu, Shigeo (Keio University)  |
|
Strain Status /
Availability
(Expected delivery) |
|
