Strain Data Sheet
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Data update: Feb 22, 2017
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RBRC No. RBRC00916  
Type Targeted MutationCartagena   wks
Species Mus musculus  
Strain name B6.Cg-Irf9<tm1Ttg>/TtgRbrc  
Former Common name IRF-9 KO/C57BL/6J ; p48<-/->; IRF-9<-/->, IRF-9 Knockout mouse, C57BL/6J  
H-2 Haplotype No Data  
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]  
Donor strain (C57BL/6 x CBA)F1 via TT2 EC cell line  
Background strain C57BL/6J Jcl  
Appearance
 1 Appearance black  
Genotype No Data  
Strain development Developed by Tadatsugu Taniguchi, Graduate School of Medicine and Faculty of Medicine, University of Tokyo. RBRC00915: Backcrossed to BALB/c (N8 generations), RBRC00916: Backcrossed to C57BL/6J (over N13 generations).  
Strain description IRF-9 gene knockout mice. Homozygous mutant mice exhibit lower serum interferon levels in response to viral infection. BALB/c background (RBRC00915), C57BL/6 background (RBRC00916).  
Colony maintenance Homozygote x Homozygote  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Irf9  
Symbol name interferon regulatory factor 9  
Chromosome 14  
Common name Irf-9, p48  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 14  
Common name neo; neomycin;  
Symbol description No Data  
References Genes Cells. 1996 Jan;1(1):115-24.  
Essential and non-redundant roles of p48 (ISGF3 gamma) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies.
Research applications Immunology and Inflammation Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT shall inform the DEPOSITOR about the purpose of the use of the BIOLOGICAL RESOURCE and shall limit the use within the scope of the purpose described in this Agreement. The RECIPIENT shall inform the DEPOSITOR about the results obtained by the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 Taniguchi Lab HP  
 2 Genetic Background  
 3 Genotyping protocol <PCR>  
Depositor Taniguchi, Tadatsugu (The University of Tokyo, Graduate School of Medicine)  Taniguchi, Tadatsugu 
Strain Status /
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