Strain Data Sheet

RBRC00960

Strain Information

Image
BRC No.RBRC00960
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Cebpb<tm1Kish>
Former Common nameNF-IL6 KO, C/ebpb<-/->
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Drs. Takashi Tanaka, Shizuo Akira and Tadamitsu Kishimoto, Institute for Molecular and Cellular Biology, Osaka University in 1995.
Strain descriptionCebpb (NF-IL6) knockout mice. Homozygous mutant mice show high neonatal mortality, susceptibility to Listeria monocytogenes and impaired tumor cytotoxicity of macrophages.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl]Homozygous mutant mice show high neonatal mortality.
ReferencesCell, 80, 353-361 (1995). 7530603

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
CebpbCCAAT/enhancer binding protein (C/EBP), beta2Cebpb<tm1Kish>targeted mutation 1, Tadamitsu KishimotoC/EBP BETA, CRP2, IL-6DBP, LAP, NF-IL6, NF-M, Nfil6

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)2neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Ordering Information

Donor DNAE. coli neo, mouse Cebpb genomic DNA, herpes simplex virus thymidine kinase promoter (HSV tk promoter)
Research application
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cell, 80, 353-361 (1995). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers.
DepositorShizuo Akira (Osaka University)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)
Lab HP

BRC mice in Publications

No Data