Strain Information | |
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Image | |
BRC No. | RBRC00960 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6;129P2-Cebpb<tm1Kish> |
Former Common name | NF-IL6 KO, C/ebpb<-/-> |
H-2 Haplotype | |
ES Cell line | |
Background strain | C57BL/6JJcl |
Appearance | black [a/a B/B C/C] |
Strain development | Developed by Drs. Takashi Tanaka, Shizuo Akira and Tadamitsu Kishimoto, Institute for Molecular and Cellular Biology, Osaka University in 1995. |
Strain description | Cebpb (NF-IL6) knockout mice. Homozygous mutant mice show high neonatal mortality, susceptibility to Listeria monocytogenes and impaired tumor cytotoxicity of macrophages. |
Colony maintenance | Heterozygote x Wild-type [C57BL/6JJcl]Homozygous mutant mice show high neonatal mortality. |
References | Cell, 80, 353-361 (1995). 7530603 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter CebpbCCAAT/enhancer binding protein (C/EBP), beta2Cebpb<tm1Kish>targeted mutation 1, Tadamitsu KishimotoC/EBP BETA, CRP2, IL-6DBP, LAP, NF-IL6, NF-M, Nfil6 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)2neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Ordering Information | |
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Donor DNA | E. coli neo, mouse Cebpb genomic DNA, herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Research application | |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cell, 80, 353-361 (1995). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers. |
Depositor | Shizuo Akira (Osaka University) |
Strain Status | Frozen sperm |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering:
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BRC mice in Publications |
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No Data |