Strain Information | |
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Image | |
BRC No. | RBRC00999 |
Type | Transgene |
Species | Mus musculus |
Strain name | B6D2-Tg(Plp1)1Kmik/Rbrc |
Former Common name | PLP-Tg |
H-2 Haplotype | |
ES Cell line | |
Background strain | Crlj:B6D2F1 |
Appearance | |
Strain development | Developed by Kazuhiro Ikenaka, Osaka University in 1989. |
Strain description | These ransgenic mice overexpress the Plp gene by introducing extra wild-type mouse proteolipid protein, PLP genes. Tg homozygous mice with 4 more Plp genes show dysmyelination in the CNS and die within about 1 month after birth. Whereas Tg hemizygous with 2 more Plp genes show normal myelination at an early age (3 weeks after birth), but later developed demyelination. |
Colony maintenance | |
References | Neuron, 13, 427-442 (1994). 7520255 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Plp1proteolipid protein (myelin) 1UNPlp1transgene insertion 1, Katsuhiko MikoshibaDM20, jimpy, jp, msd, myelin synthesis deficiency, rsh, rump shakermouse proteolipid protein (myelin) promoter (20 kb) Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)UN |
Ordering Information | |
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Donor DNA | C57BL/6 mouse Plp1 genomic DNA, cosmid vector LoristB (E. coli neo) |
Research application | Neurobiology Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Neuron, 13, 427-442 (1994). |
Depositor | Kazuhiro Ikenaka (National Institute for Physiological Sciences) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |