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RBRC No. |
RBRC01122
|
|
Type |
Transgene Congenic |
 |
|
Species |
Mus musculus |
|
Strain name |
hRN 8-12 |
|
Former Common name |
No Data |
|
H-2 Haplotype |
No Data |
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Background strain |
C57BL/6J |
|
Appearance |
| 1 |
Appearance |
black |
| Genotype |
a/a B/B C/C |
|
Strain development |
The transgenic mouse with integration of 10 copies of a 15 kbp human DNA fragment containing the renin gene. The mice with high blood pressure can be produced by crossbreeding this mouse with the hAG transgenic mice. Angiotensinogen is a component of the renin-angiotensin system that regulates constriction of the blood vessel, and maintain high blood pressure. In this system, renin secreted by a kidney acts on angiotensinogen, and angiotensin I are produced. Furthermore, angiotensin I is converted into angiotensin II having strong vasoconstriction effect by the action of a converting enzyme which exists in a liver and each organ. |
|
Strain description |
Developed by Dr. Akiyoshi Fukamizu at University of Tsukuba in 1991. The transgenic mouse with integration of 10 copies of a 15 kbp human DNA fragment containing the renin gene. This strain was backcrossed to C57BL/6 for three times. |
|
Colony maintenance |
Sibling Mating
Homozygous mice are viable and fertile. |
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Animal health report |
|
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Gene Details |
|
Promoter |
No Data |
| 1 |
Symbol |
REN1 |
| Symbol name |
renin 1 structural (human) |
| Chromosome |
UN |
| Common name |
Ren, Ren-1, Ren-A, Ren1d, Rn-1, Rnr |
| Symbol description |
No Data |
|
References |
Biochem Biophys Res Commun. 1989 Dec 15;165(2):826-32. Tissue-specific expression of the human renin gene in transgenic mice. |
|
Research applications |
Cell Biology Research,
Hematological Research |
|
Specific Term and Conditions |
The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Biochemical and Biophysical Research Communications, 165, 826-832 (1989).
Within a period of 2 years after deposition of the material, user must contact bailor and notify him a content of the research. If the bailor judges that the research should be a collaborative work, then user must include bailor and/or developer's names as co-authors. |
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Additional information |
|
1 |
Lab HP (Japanese) |
|
2 |
Mouse of the Month May 2012
Systolic blood pressure
Genetic Background |
|
3 |
Genotyping protocol <PCR> |
|
Depositor |
Fukamizu, Akiyoshi (University of Tsukuba)  |
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Strain Status /
Availability
(Expected delivery) |
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