Strain Data Sheet

RBRC01229

Strain Information

Image
BRC No.RBRC01229
TypeTargeted Mutation and Chromosomal Aberration and F2 HybridCartagena
SpeciesMus musculus
Strain nameB6;129-Foxh1<tm1.1Hmd>/HmdRbrc
Former Common nameB6;129-FoxH1+/-, FAST+/-, B6;129-FoxH1tm1Hh(B6;129-FoxH1+/-,FAST+/- ) knockout mice
H-2 Haplotype
ES Cell lineR1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]
Background strain
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Drs. Masamichi Yamamoto and Hiroshi Hamada at Osaka University in 2001. Foxh1<tm1.1Hmd> mutant mice were generated from Foxh1<tm1Hmd> mutant mice by crossing with cre-expressing line, Tg(ACTB-cre)Miya mice strain.
Strain descriptionB6;129-Foxh1<tm1.1Hmd>. The transcription factor Foxh1 (horkhead box H1) mediates signaling by transforming growth factor-β, Activin, and Nodal. Foxh1 null deficient mice are perinatal lethal. The embryos of Foxh1 deficient mice exhibit various patterning defects by the loss of Nodal signaling. This mice are useful for the study of Foxh1 gene in vivo.
Colony maintenanceBackcross to C57BL/6 (Heterozygote x C57BL/6Cr)Homozygous mutant mice are perinatal lethal.
ReferencesGenes Dev., 15, 1242-1256 (2001). 11358868

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
FoxH1forkhead box H115FoxH1<tm1.1Hmd>targeted mutation 1.1, Hiroshi HamadaFAST

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP15loxP

Ordering Information

Donor DNAphage P1 loxP, mouse FoxH1 genomic DNA
Research applicationCre/loxP system
Developmental Biology Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genes Dev., 15, 1242-1256 (2001).
DepositorHiroshi Hamada (RIKEN CDB)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

No Data