Strain Data Sheet

RBRC01293

Strain Information

Image
BRC No.RBRC01293
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129-Psap<tm1Juma>/Rbrc
Former Common nameSaposin D mutant mouse
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Dr. Junko Matsuda, the University of Tokushima Graduate School and Dr. Kunihiko Suzuki, University of North Carolina at 2004.
Strain descriptionHomozygous mutant mice exhibit renal tubular degeneration around 2 months, and a cerebellar Purkinje cell degeneration around 4 months with accumulation of hydroxy fatty acid-containing ceramide. Average life sopan is 10-15 months.
Colony maintenanceBackcross to C57BL/6 (Heterozygote x C57BL/6JJcl)
ReferencesHum. Mol. Genet., 13, 2709-2723 (2004). 15345707

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Psapprosaposin10Psap<tm1Jmat>targeted mutation 1, Junko MatsudaSGP-1, snoRNA MBII-198

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP10loxP

Ordering Information

Donor DNAPhage P1 loxP site, mouse prosaposin genomic DNA
Research applicationCre/loxP system
Neurobiology Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Hum. Mol. Genet., 13, 2709-2723 (2004).
DepositorJunko Matsuda (Tokushima University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-
Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data