Strain Information | |
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Image | |
BRC No. | RBRC01293 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6;129-Psap<tm1Juma>/Rbrc |
Former Common name | Saposin D mutant mouse |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Dr. Junko Matsuda, the University of Tokushima Graduate School and Dr. Kunihiko Suzuki, University of North Carolina at 2004. |
Strain description | Homozygous mutant mice exhibit renal tubular degeneration around 2 months, and a cerebellar Purkinje cell degeneration around 4 months with accumulation of hydroxy fatty acid-containing ceramide. Average life sopan is 10-15 months. |
Colony maintenance | Backcross to C57BL/6 (Heterozygote x C57BL/6JJcl) |
References | Hum. Mol. Genet., 13, 2709-2723 (2004). 15345707 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP10loxP |
Ordering Information | |
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Donor DNA | Phage P1 loxP site, mouse prosaposin genomic DNA |
Research application | Cre/loxP system Neurobiology Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Hum. Mol. Genet., 13, 2709-2723 (2004). |
Depositor | Junko Matsuda (Tokushima University) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Genotyping protocol -PCR- Necessary documents for ordering: |
BRC mice in Publications |
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No Data |