|
RBRC No. |
RBRC01297
|
|
Type |
Transgene |
 |
|
Species |
Mus musculus |
|
Strain name |
DBH-Cre/6-8 |
|
Former Common name |
No Data |
|
H-2 Haplotype |
No Data |
|
Background strain |
C57BL/6J |
|
Appearance |
| 1 |
Appearance |
black |
| Genotype |
a/a B/B C/C |
|
Strain development |
Developed by Kazuto Kobayashi, Fukushima Medical University School of Medicine in 1998. The transgene was injected into the pronuclei of B6D2F2 fertilized eggs. The transgenic mice were backcrossed to C57BL/6J. |
|
Strain description |
These transgenic mice express Cre recombinase gene under the control of the human dopamin beta hydroxylase (DBH) gene promoter. This strain can be used to make an inducible knock-out by crossing with the other genetically-engineered mice that have a loxP site-flanked sequence of interest. The recombination occurs in typical noradrenergic and adrenergic cell groups as well as in transient catecholaminergic cell types. |
|
Colony maintenance |
Carrier x Noncarrier [C57BL/6JJcl] Tg mice are viable and fertile. |
|
Animal health report |
|
|
Gene Details |
|
Promoter |
human dopamine beta-hydroxylase (DBH) promoter, rabbit beta-globin intron, rabbit beta-globin poly A, SV40 early gene poly A |
| 1 |
Symbol |
cre |
| Symbol name |
Phage P1 Cre recombinase |
| Chromosome |
UN |
| Common name |
No Data |
| Symbol description |
No Data |
|
References |
J Neurosci Res. 2004 Oct 1;78(1):7-15. Fate of transient catecholaminergic cell types revealed by site-specific recombination in transgenic mice. |
|
Research applications |
Cell Biology Research,
Cre/loxP system,
Neurobiology Research |
|
Specific Term and Conditions |
The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Neursci. Res., 78, 7-15 (2004).
The RECIPIENT agrees to include the DEPOSITOR as a co-author in any publications resulted by the use of the BIOLOGICAL RESOURCE during the first 2 years after deposition by the DEPOSITOR to the RIKEN BRC. |
|
Additional information |
|
1 |
Lab HP (Japanese) |
|
2 |
Mouse of the Month Jun 2005
Mouse of the Month June 2006 |
|
3 |
Genotyping protocol <PCR> |
|
Depositor |
Kobayashi, Kazuto (Fukushima Medical University)  |
|
Strain Status /
Availability
(Expected delivery) |
|
