Strain Data Sheet

RBRC01387

Strain Information

Image
BRC No.RBRC01387
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Ncdn<tm2Afu>/AfuRbrc
Former Common nameNC<lox/lox>
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain developmentDeveloped by Akiyoshi Fukamizu, University of Tsukuba in 2004.
Strain descriptionNeurochondrin conditional knock-out mice. The neural tissue-specific neurochondrin is disrupted by Cre-loxP system. Neurochondorin is a cytoplasmic protein involve in neurite outgrowth, chondrocyte differentiation, and bone metabolizm. The nervous system specific deficient mice show that the Ncdh gene is a negative regulator to CaMKII (Ca/calmodulin-dependent protein kinase II) and essential for the spatial learning prosess.
Colony maintenance
ReferencesJ. Biol. Chem., 280, 20503-20508 (2005). 15790563

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
NcdnNeurochondrin4Ncdn<tm2Afu>targeted mutation 2, Akiyoshi FukamizumKIAA0607, neurochondrin-1, neurochondrin-2, norbin

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP4loxP

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP4loxP

Ordering Information

Donor DNAphage P1 loxP sites, mouse Neurochondrin genomic DNA
Research applicationCre/loxP system
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Biol. Chem., 21, 20503-20508 (2005).
DepositorAkiyoshi Fukamizu (University of Tsukuba)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)
Lab HP (Japanese)
Genotyping protocol -PCR-

BRC mice in Publications

No Data