Strain Data Sheet
RBRC01395
Strain Information | |
|---|---|
| Image | |
| BRC No. | RBRC01395 |
| Type | Transgene |
| Species | Mus musculus |
| Strain name | C57BL/6-Tg(tetO-AML1/MTG8)1/Rbrc |
| Former Common name | TOAM8G mice |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | |
| Appearance | |
| Strain development | Developed by Dr. Kiwamu Akagi at 1999. The human AML1-MTG8 chimeric gene was injected into C57BL/6 fertilized eggs. |
| Strain description | This transgenic mice express a AML1-MTG8 chimeric gene that is activated by the TetR-transactivator. This strain is useful for model mouse of leukemia. |
| Colony maintenance | |
| References | |
Health Report | |
|---|---|
| Examination Date / Room / Rack | |
Gene | |
|---|---|
| Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter CBFA2T1HCBFA2T1 identified gene homolog (human)UNCBFA2T1HETO, MTG8 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter RUNX1runt related transcription factor 1 (human)UNRUNX1AML1, Cbfa2, Pebp2a2, runt domain, alpha subunit 2 |
Ordering Information | |
|---|---|
| Donor DNA | human CMV mini promoter with heptamerized tet-operators upstream, rabbit beta-globin poly A, human AML1-MTG8 cDNA |
| Research application | Tet system |
| Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT agrees to include the DEPOSITOR/DEVELOPER as a co-author in any publications resulted by the use of the BIOLOGICAL RESOURCE during the first 2 years after deposition by the DEPOSITOR to the RIKEN BRC. |
| Depositor | Kiwamu AKAGI (Saitama Cancer Center) |
| Strain Status |  Frozen embryos |
| Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
|---|
| No Data |