Strain Information | |
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Image | |
BRC No. | RBRC01458 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.129-Dpt<tm1Hsh>/NakaRbrc |
Former Common name | Dermatopontin KO mice |
H-2 Haplotype | |
ES Cell line | R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>] |
Background strain | C57BL/6JJcl |
Appearance | black [a/a B/B C/C] |
Strain development | Developed by Dr. Hroshi Shinkai, Chiba University at 2002. A pgk-neo was transfered into ES cells to relpace exon 1 of Dpt gene. |
Strain description | Dermatopontin (Dpt) is a collagen-associated protein, is widely distributed in extracellular matrix. Homozygote mutant mice not exhibit any obvious anatomical abnormality, but the skin elasticity was increased. This strain is useful for study of the mechanism and the process of collagen fibrillogenesis. |
Colony maintenance | Backcross to C57BL/6 (Heterozygote x C57BL/6JJcl)Homozygote mutant mice are fertile. |
References | J. Invest. Dermatol., 119, 678-683 (2002). 12230512 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter DptDermatopontin1Dpt<tm1Hsh>targeted mutation 1, Hiroshi Shinkai1810032B19Rik, 5033416F05Rik, early quiescence protein-1, EQ-1 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)1neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Ordering Information | |
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Donor DNA | herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, HSV tk polyA, mouse Dpt genomic DNA |
Research application | Cell Biology Research Dermatology Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Invest. Dermatol., 119, 678-683 (2002). |
Depositor | Toshinori Nakayama (Chiba University) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |