Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jul 24, 2014
Health Certificate   PCR Protocol   Thawing Method
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RBRC No. RBRC01459  
Type TransgeneCartagena   wks
Species Mus musculus  
Strain name P0Cre-A  
Former Common name No Data  
H-2 Haplotype No Data  
Background strain FVB/N  
Appearance
 1 Appearance albino  
Genotype a/a B/B C/C  
Strain development Developed by Dr. Marco Giovannini at INSERM, France in 2000. P0Cre transgene fragment consisting of P1 Cre recomnbinase and 1.1 kb rat P0 promoter was injected into the pronuclei of FVB/N fertilized egges.  
Strain description FVB/N-Tg(P0-Cre)1Gth. P0Cre contains a transcriptional unit consisting of a Schwann cell specific promoter (myelin protein zero promoter) and Cre recombinase gene. This strain can be used to make a inducible knock-out by crossing with other conditional knock out mice that have floxed genes. P0Cre is a driver mouse that can remove floxed genes only in the myelin of the PNS.  
Colony maintenance Sibling Mating  
Health Certificate
    BRC facility Health Certificate 2012.10-2014.5
Gene Details
Promoter No Data  
 1 Symbol nls  
Symbol name Simian virus 40 Large T antigen nuclear localization signal  
Chromosome UN  
Common name No Data  
Symbol description No Data  
Promoter rat P0 promoter, rabbit beta-globin intron and polyadenylation signal  
 2 Symbol cre  
Symbol name Phage P1 Cre recombinase  
Chromosome UN  
Common name No Data  
Symbol description No Data  
References Genes Dev. 2000 Jul 1;14(13):1617-30.  
Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2.
Research applications Cre/loxP system  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Genes & Development, 14, 1617-1630 (2000).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
RECIPIENT shall keep DEPOSITOR apprised of any results obtained from the BIOLOGICAL RESOURCE in the course of the research, as soon as they are available. Moreover, if the research results in a potential invention or a substance that may have potential commercial value (hereinafter referred as to the "Invention") RECIPIENT will promptly disclose this Invention to DEPOSITOR with samples thereof for DEPOSITOR's internal use.
RECIPIENT and DEPOSITOR will consult together and agree about the possibility of filing one or more patent application to Invention conceived by one or more employees of Recipients that directly arise out of the research. The Parties will negotiate in good faith the conditions of such patent application according to each party's inventiveness contribution in the Invention.
In case of such Invention, patentable or not, reduced in practice or developed in the course of the research that could not have been obtained, reduced to practice or developed but from using the Material and/or Confidential Information, RECIPIENT and DEPOSITOR shall confer with one another as regards licensing and commercialization of such Invention to negotiate in good faith the terms of an institutional agreement as regards said matters.  
Additional information
 1 Contact Information  
 2 Genetic Background  
 3 Genotyping protocol <PCR>  
Depositor Giovannini, Marco (House Ear Institute)  Giovannini, Marco 
Strain Status /
Availability
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