Strain Information | |
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Image | |
BRC No. | RBRC01730 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | C.129S2-Ptprc<tm1Tyb>/Rbrc |
Former Common name | CD45 knockout mouse |
H-2 Haplotype | |
ES Cell line | |
Background strain | BALB/cAnNCrlCrlj |
Appearance | |
Strain development | Developed by Dr. Victor L J Tybulewicz at National Institute for Medical Research in 1999. A neo was transfered into D2 ES cells to reolace the exon 12 of the Ptprc gene. BALB/c background. |
Strain description | CD45 is a transmembrane tyrosine phosphatase implicated in the control of T cell receptor signaling. CD45 homozygous mutant mice in the BALB/c background were gorssly normal and fertile. |
Colony maintenance | Backcross to BALB/c (Heterozygote x BALB/cAnN) |
References | Eur. J. Immunol., 29, 2923-2933 (1999). 10508267 |
Health Report | |
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Examination Date / Room / Rack | 2024/02/26Room:4-BRack:D |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Ptprcprotein tyrosine phosphatase, receptor type, C1Ptprc<tm1Tyb>targeted mutation 1, Victor L J TybulewiczB220, CD45, Cd45, CD45R, Ly-5, LY-5, Lyt-4, T200 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)1neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter) Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter poly AHSV TK polyA1poly A |
Ordering Information | |
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Donor DNA | mouse Phosphoglycerate kinase-1 (PGK) promoter, E.coli neo, HSV TK PolyA, mouse CD45 genomic DNA |
Research application | Immunology and Inflammation Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Eur. immunol., 29, 2923-2933 (1999).Research Purpose only. The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEVELOPER (Dr. Victor Tybulewicz). |
Depositor | Shigeo Koyasu (Keio University) |
Strain Status | Live mice Frozen embryos Frozen sperm |
Strain Availability | Cryopreserved sperm (within 1 month) Live mouse (3 to 6 months) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |