Strain Information | |
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Image | |
BRC No. | RBRC01817 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.129P2-Drd4<tm1(IL2RA)Tao>/KobaRbrc |
Former Common name | D4R-IL-2R |
H-2 Haplotype | |
ES Cell line | E14 [129P2/OlaHsd] |
Background strain | C57BL/6JJcl |
Appearance | black [a/a B/B C/C] |
Strain development | Developed by Dr. Kazuto Kobayashi, Fukushima Medical University School of Medicine in 1998. |
Strain description | B6.129P2-Drd4<tm1(IL2RA)Tao. The human interleukin-2 receptor alpha-subunit gene and neo cassettes were introduced into exon 2 of mouse D4R gene. Specific neurons expressing D4R gene of this mice are disrupted by a recombinant immunotoxin. |
Colony maintenance | Backcross to C57BL/6 (Heterozygote x C57BL/6JJcl) |
References | J. Neurosci. 23, 11662-11672 (2003). 14684868 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter HBB2rabbit beta-globin polyA7HBB2 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter IL2RAInterleukin-2 receptor α-subunit (human)7IL2RA Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)7neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter) Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter SV40 polyA7 |
Ordering Information | |
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Donor DNA | mouse D4R genomic DNA, human interleukin-2 receptor α subunit, rabbit β globin poly A signal, mouse phosphoglycerate kinase-1 promoter, E. coli neo, SV40 poly A signal |
Research application | Neurobiology Research |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Neurosci. 23 (37) 11662-11672 (2003). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
Depositor | Kazuto Kobayashi (Fukushima Medical University) |
Strain Status | Frozen embryos |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |