Strain Data Sheet
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Data update: Jun 21, 2017
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RBRC No. RBRC01888  
Type Spontaneous Mutation Congenic  
Species Mus musculus  
Strain name C57BL/6-Wsh/Wsh  
Former Common name W sash  
H-2 Haplotype No Data  
Background strain C57BL/6  
Appearance
 1 Appearance black  
Genotype a/a B/B C/C +/+  
 2 Appearance white, black eyes  
Genotype a/a B/B C/C Sh/Sh  
 3 Appearance black with white spotting  
Genotype a/a B/B C/C Sh/+  
Strain development Developed by Keisuke Oboki, RIKEN Research Center for Allergy anf Immunology. This strain was generated by backcrossing to C57BL/6 from C;B6-a/a-b/b-W<sh>/W<sh> strain (RBRC00762).  
Strain description The Kit<W-sh> mutation arose spontaneously in the (C3H/HeN x 101/H)F1 at the MRC (Lyon et al., 1982). Homozygous mice are white coat with black eyes. Heterozygotes are black with a white sash. This strain is useful for study of melanogenesis and neural crest migration.  
Colony maintenance Heteryozygote x Homozygote. Homozygous mutant mice are viable and fertile.  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Kit  
Symbol name kit oncogene  
Chromosome 5  
Common name belly-spot, c-KIT, CD117, Dominant white spotting, Steel Factor Receptor, Tr-kit  
Symbol description No Data  
References Am J Pathol. 2005 Sep;167(3):835-48.
Blood. 1992 Sep 15;80(6):1448-53.
Blood. 1994 Jun 15;83(12):3509-16.
Blood. 1999 Oct 15;94(8):2658-66.
Development. 1993 Jul;118(3):705-17.
Genet Res. 1982 Jun;39(3):315-22.  
Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
Research applications Dermatology Research,
Immunology and Inflammation Research  
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)  
Additional information
 1 Genetic Background  
 2 Genotyping protocol <PCR>  
Depositor Oboki, Keisuke (The Institute of Physical and Chemical Research)  Oboki, Keisuke 
Strain Status /
Availability
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