Strain Information | |
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Image | |
BRC No. | RBRC02102 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.Cg-Arpc3<tm1Jtak>/JtakRbrc |
Former Common name | Arpc3-KO |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | black [a/a B/B C/C] |
Strain development | Developed by Dr. Junji Takeda at Osaka University in 2005. A PGK-neo selection cassette replaced a fragment of exon 2 of Arpc3 gene. |
Strain description | Arpc3 is a component of the Arp2/3 complex, which plays a major role in actin nucleation, filament binding, and Y-shaped branching to reorganize filamentous actin in response to extrinsic or intrinsic signaling for cell motility. |
Colony maintenance | Backcross to C57BL/6 (Heterozygote x C57BL/6J) |
References | Mol. Cell. Biol., 26, 6185-6196 (2006). 16880528 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Arpc3actin related protein 2/3 complex, subunit 35Arpc3<tm1Jtak>targeted mutation 1, Junji Takeda1110006A04Rik, Arp2/3 complex subunit p21-Arc, p21-Ar Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)5neo; neomycin; |
Ordering Information | |
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Donor DNA | mouse Arpc3 genomic DNA, E. coli neo, mouse phosphoglycerate kinase promoter (PGK promoter) |
Research application | Cell Biology Research |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Mol. Cell. Biol., 26, 6185-6196 (2006).RECIPIENT which wants to use the BIOLOGICAL RESOURCE for the purpose other than education or not-for-profit research is requested to enter into a Material Transfer Agreement with Osaka University. |
Depositor | Junji Takeda (Osaka University) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |