Strain Data Sheet

RBRC02294

Strain Information

Image
BRC No.RBRC02294
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-p130Cas<tm1.2Homy>
Former Common nameCas-ex2<+/->
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearance
Strain developmentDeveloped by Dr. Hiroaki Honda, Research Institute for Radiation Biology and Medicine, Hiroshima University in 2003.
Strain descriptionCasp130 (Crk-associated substrate p130) knockout mice. This mice were generated by the micro-injection of the vector to express Cre recombinase into the eggs of conditional KO strain that have flanked exon 2 encoding SH3 domain of Casp130. Homozygous mutant mice are embryonic lethal.
Colony maintenancebackcross to C57BL/6N (Heterozygote x C57BL/6NCrlCrlj)
ReferencesHepatology, 52(3), 1089-1099 (2010). 20623582

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Bcar1breast cancer anti-estrogen resistance 18Bcar1<tm1.2Homy>targeted mutation 1.2, HomyCas, Crkas, p130 Cas

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Frtyeast FRT (flippase recombination target) site8Frt

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP8loxP

Ordering Information

Donor DNAphage P1 loxP site, yeast (Saccharomyces cerevisiae) FRT site, mouse Cas genomic DNA
Research applicationCell Biology Research
Cre/loxP system
FLP/frt system
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
DepositorHiroaki Honda (Tokyo Women's Medical University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)
Lab HP (Japanese)

BRC mice in Publications

No Data