Strain Data Sheet
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Data update: Feb 21, 2014
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RBRC No. RBRC02298  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name C.Cg-Il3<tm1Glli>  
Former Common name IL-3 knock-out mouse  
H-2 Haplotype No Data  
Background strain BALB/c  
Appearance
 1 Appearance albino  
Genotype A/A b/b c/c  
Strain development Developed by Dr. Glenn Dranoff, Dana-Farber Cancer Institute, Harvard Medical School in 1998. Mutant mice were backcrossed to C57BL/6 for 9 gnerations, and then to BALB/cAnNTac for 3 generations. Deposited by Dr. Shigeo Koyasu, Keio University School of Medicine.  
Strain description Interluekin-3 is a growth factor of hematopoieic progenitors that yields multipotential blast cells, mast cells, basophils,neutrophils, macrophages, eosinophils, erythrocytes, megakaryocytes, and dendritic cells. IL-3 null mutant mice show unimpaired hematopoiesis, but contact hypersensitivity reactions are compromised.  
Colony maintenance Backcross to BALB/c (Heterozygote x BALB/cAnNTac)  
Health Certificate
Gene Details
Promoter No Data  
 1 Symbol Il3  
Symbol name Interleukin 3  
Chromosome 11  
Common name BPA, Csfmu, HCGF, Il-3, MCGF, PSF  
Symbol description No Data  
 2 Symbol poly A  
Symbol name mouse PGK poly A  
Chromosome 11  
Common name No Data  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 3 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 11  
Common name neo; neomycin;  
Symbol description No Data  
References   
Research applications Immunology and Inflammation Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOER (Glenn Dranoff, MD Harvard Medical School, Dana-Farber Cancer Institute E-mail: glenn_dranoff@dfci.harvard.edu).  
Additional information
 1 Lab HP  
 2 Genotyping protocol <PCR>  
Depositor Koyasu, Shigeo (Keio University)  Koyasu, Shigeo 
Strain Status /
Availability
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