|
RBRC No. |
RBRC02298
|
|
Type |
Targeted Mutation |
 |
|
Species |
Mus musculus |
|
Strain name |
C.Cg-Il3<tm1Glli> |
|
Former Common name |
IL-3 knock-out mouse |
|
H-2 Haplotype |
No Data |
|
Background strain |
BALB/c |
|
Appearance |
| 1 |
Appearance |
albino |
| Genotype |
A/A b/b c/c |
|
Strain development |
Developed by Dr. Glenn Dranoff, Dana-Farber Cancer Institute, Harvard Medical School in 1998. Mutant mice were backcrossed to C57BL/6 for 9 gnerations, and then to BALB/cAnNTac for 3 generations. Deposited by Dr. Shigeo Koyasu, Keio University School of Medicine. |
|
Strain description |
Interluekin-3 is a growth factor of hematopoieic progenitors that yields multipotential blast cells, mast cells, basophils,neutrophils, macrophages, eosinophils, erythrocytes, megakaryocytes, and dendritic cells. IL-3 null mutant mice show unimpaired hematopoiesis, but contact hypersensitivity reactions are compromised. |
|
Colony maintenance |
Backcross to BALB/c (Heterozygote x BALB/cAnNTac) |
|
Animal health report |
|
|
Gene Details |
|
Promoter |
No Data |
| 1 |
Symbol |
Il3 |
| Symbol name |
Interleukin 3 |
| Chromosome |
11 |
| Common name |
BPA, Csfmu, HCGF, Il-3, MCGF, PSF |
| Symbol description |
No Data |
| 2 |
Symbol |
poly A |
| Symbol name |
mouse PGK poly A |
| Chromosome |
11 |
| Common name |
No Data |
| Symbol description |
No Data |
|
Promoter |
mouse phosphoglycerate kinase promoter (PGK promoter) |
| 3 |
Symbol |
neo |
| Symbol name |
neomycin resistance gene (E. coli) |
| Chromosome |
11 |
| Common name |
neo; neomycin; |
| Symbol description |
No Data |
|
References |
|
|
Research applications |
Immunology and Inflammation Research |
|
Specific Term and Conditions |
The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOER (Glenn Dranoff, MD Harvard Medical School, Dana-Farber Cancer Institute E-mail: glenn_dranoff@dfci.harvard.edu). |
|
Additional information |
|
1 |
Lab HP |
|
2 |
Genotyping protocol <PCR> |
|
Depositor |
Koyasu, Shigeo (Keio University)  |
|
Strain Status /
Availability
(Expected delivery) |
|
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