Strain Data Sheet

RBRC02330

Strain Information

Image
BRC No.RBRC02330
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameNOD.Cg-Fcer1g<tm1Rav> Fcgr2b<tm1Ttk>
Former Common nameNODFcγRnull
H-2 Haplotype
ES Cell line
Background strain
Appearancealbino [A/A c/c]
Strain developmentDeveloped by Drs. Y. Inoue and T. Takai, Tohoku University in 2004.
Strain descriptionFcR common gamma-chain (Fc-Rgamma) deficient mice. NOD background.
Colony maintenanceSibling Mating (Homozygote x Homozygote)This strain shows less severe insulitis, whereas after the onset of diabetes, homozygous and wild-type mice shows cimparable nsulitis indices.
ReferencesJ. Immunol., 179, 764-774 (2007). 17617565
Nature, 379, 346-349 (1996). 8552190
Cell, 76(3):519-29 (1994). 8313472

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide1Fcer1g<tm1Rav>targeted mutation 1, Jeffrey V RavetchFce1g, FcR-gamma, FcR[g], FcRgamma, Ly-50

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Fcgr2bFc receptor, IgG, low affinity IIb1Fcgr2b<tm1Ttk>targeted mutation 1, Toshiyuki Takai

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)1neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)1neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Ordering Information

Donor DNAherpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse Fcer1g genomic DNA, mouse Fcgr2b genomic DNA
Research applicationImmunology and Inflammation Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Immunol., 179, 764-774 (2007).
DepositorToshiyuki Takai (Tohoku University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

Kayes T, Fang Y, Yu S, Downey E, Wang S, Braley-Mullen H.
Agonistic anti-CD40 induces thyrocyte proliferation and promotes thyroid autoimmunity by increasing CD40 expression on thyroid epithelial cells.
J Immunol 190(8) 3928-38(2013) 23509363

Umemoto S, Nakahashi-Ouchida R, Yuki Y, Kurokawa S, Machita T, Uchida Y, Mori H, Yamanoue T, Shibata T, Sawada SI, Ishige K, Hirano T, Fujihashi K, Akiyoshi K, Kurashima Y, Tokuhara D, Ernst PB, Suzuki M, Kiyono H.
Cationic-nanogel nasal vaccine containing the ectodomain of RSV-small hydrophobic protein induces protective immunity in rodents.
NPJ Vaccines 8(1) 106(2023) 37488116