|
RBRC No. |
RBRC02370
|
|
Type |
Targeted Mutation |
 |
|
Species |
Mus musculus |
|
Strain name |
B6;129-Grn<tm1> |
|
Former Common name |
Progranulin knock-out mouse |
|
H-2 Haplotype |
No Data |
|
Background strain |
C57BL/6 |
|
Appearance |
| 1 |
Appearance |
black |
| Genotype |
a/a B/B C/C |
|
Strain development |
Developed by Masugi Nishihara, Veterinary Medical Science, The University of Tokyo and Yoichiro Iwakura, Institute of Medical Science, The University of Tokyo in 2001. Targeting construct was electoroporated into E14.1 ES cells derived from 129P2/OlaHsd. |
|
Strain description |
Grn, granulin knockout mice. A 4.7 kb fragment encoding exon 2-13 of Grn gene was replaced with a PGK-neo-bpA cassette. Homozygous mutant mice show a decrease in ejaculation incidence, enhanced aggressiveness and an elevated level of anxiety in male. |
|
Colony maintenance |
Heterozygote x Wild-type [C57BL/6JJmsSlc]. |
|
Animal health report |
|
|
Gene Details |
|
Promoter |
No Data |
| 1 |
Symbol |
Grn |
| Symbol name |
granulin |
| Chromosome |
11 |
| Common name |
acrogranulin, epithelin, PC cell-derived growth factor, progranulin |
| Symbol description |
No Data |
| 2 |
Symbol |
poly A |
| Symbol name |
bovine growth hormone poly adenylation signal sequence |
| Chromosome |
11 |
| Common name |
No Data |
| Symbol description |
No Data |
|
Promoter |
mouse phosphoglycerate kinase promoter (PGK promoter) |
| 3 |
Symbol |
neo |
| Symbol name |
neomycin resistance gene (E. coli) |
| Chromosome |
11 |
| Common name |
neo; neomycin; |
| Symbol description |
No Data |
|
References |
Behav Brain Res. 2007 Jul 20;. Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene. |
|
Research applications |
Neurobiology Research |
|
Specific Term and Conditions |
The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Behav. Brain. Res., 185, 110-118 (2007).
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. |
|
Additional information |
|
1 |
Genetic Background |
|
2 |
Genotyping protocol <PCR> |
|
Depositor |
Nishihara, Masugi (The University of Tokyo)  |
|
Strain Status /
Availability
(Expected delivery) |
|
