Strain Information | |
---|---|
Image | |
BRC No. | RBRC02432 |
Type | Transgene |
Species | Mus musculus |
Strain name | (hRN8-12 x hAG2-5)F1 |
Former Common name | |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Dr. Akiyoshi Fukamizu, University of Tsukuba in 1991. C57BL/6 background. |
Strain description | Tsukuba Hypertensive Mice. |
Colony maintenance | |
References | Biochem. Biophys. Res. Commun., 165, 826-832 (1989). 2480785 Biochem. Biophys. Res. Commun., 180, 1103-1109 (1991). 1659395 |
Health Report | |
---|---|
Examination Date / Room / Rack |
Gene | |
---|---|
Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter AGTAngiotensinogen (human)UNAGT Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter REN1renin 1 structural (human)UNREN1 |
Ordering Information | |
---|---|
Donor DNA | human angiotensinogen genomic DNA ,human renin1 genomic DNA (10 exons, 9 introns and native promoter) |
Research application | Cell Biology Research Hematological Research Mouse Models for Human Disease covid19_progression |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Biochemical and Biophysical Research Communications, 165, 826-832 (1989). Biochemical and Biophysical Research Communications, 180, 1103-1109 (1991). |
Depositor | Akiyoshi Fukamizu (University of Tsukuba) |
Strain Status | Live mice Frozen embryos |
Strain Availability | Cryopreserved embryos (within 1 month) Live mouse (3 to 6 months) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- Mouse of the Month May 2012 Systolic blood pressure |
BRC mice in Publications |
---|
Inui Y, Mochida H, Yamairi F, Okada M, Ishida J, Fukamizu A, Arakawa K. Effects of aging and uninephrectomy on renal changes in Tsukuba hypertensive mice. Biomed Rep 1(3) 359-364(2013) 24648949 Kawarazaki W, Nagase M, Yoshida S, Takeuchi M, Ishizawa K, Ayuzawa N, Ueda K, Fujita T. Angiotensin II- and salt-induced kidney injury through Rac1-mediated mineralocorticoid receptor activation. J Am Soc Nephrol 23(6) 997-1007(2012) 22440899 Suzuki D, Saito-Hakoda A, Ito R, Shimizu K, Parvin R, Shimada H, Noro E, Suzuki S, Fujiwara I, Kagechika H, Rainey WE, Kure S, Ito S, Yokoyama A, Sugawara A. Suppressive effects of RXR agonist PA024 on adrenal CYP11B2 expression, aldosterone secretion and blood pressure. PLoS One 12(8) e0181055(2017) 28800627 |