Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Mar 22, 2017
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RBRC No. RBRC02711  
Type Targeted MutationCartagena   wks
Species Mus musculus  
Strain name B6.129S-Osmr<tm1Mtan>  
Former Common name Oncostatin M receptor knockout mouse, OSMR-KO  
H-2 Haplotype No Data  
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]  
Background strain C57BL/6  
Appearance
 1 Appearance black  
Genotype a/a B/B C/C  
Strain development Developed by Dr. Minoru Tanaka in 1999.  
Strain description Osmr knock-out mice. Osmr, Oncostain M receptor is an alternative subunit that activated by Osm. Osm is a multifunctional cytokine that belongs to the interleukin 6 family, considered to play a role in hematopoiesis. Homozygous mutant mice are viable and fertile, but show a mild anemia and recovery delay of erythrocytes from chemically induced acute hemolysis.  
Colony maintenance Heterozygote x Wild-type [C57BL/6CrSlc]  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Osmr  
Symbol name oncostatin M receptor  
Chromosome 15  
Common name OSMRB  
Symbol description No Data  
 2 Symbol lacZ  
Symbol name beta-galactosidase (E. coli)  
Chromosome 15  
Common name No Data  
Symbol description E. coli beta galactosidase  
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)  
 3 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 15  
Common name neo; neomycin;  
Symbol description No Data  
References Blood 2003 Nov 1;102(9):3154-62. Epub 2003 Jul 10.
Hepatology 2004 Mar;39(3):635-44.  
Targeted disruption of oncostatin M receptor results in altered hematopoiesis.
Targeted disruption of oncostatin M receptor results in altered hematopoiesis.
Research applications Hematological Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Blood, 102, 3154-3162 (2003). Hepatology, 39, 635-644 (2004).
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on
use of it from the DEVELOPER (Chiome Bioscience Inc. Email:knakamura@chiome.co.jp).  
Additional information
 1 Lab HP (Japanese)  
 2 Genotyping protocol <PCR>  
Depositor Miyajima, Atsushi (The University of Tokyo)  Miyajima, Atsushi 
Strain Status /
Availability
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