Strain Information | |
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Image | |
BRC No. | RBRC02771 |
Type | Transgene |
Species | Mus musculus |
Strain name | C.B-17/Icr Prkdc<scid>-Tg(INS-TRECK/DTR)1Rin |
Former Common name | BALB/c Prkdc<scid>-Tg(INS-TRECK/DTR)1Rin |
H-2 Haplotype | |
ES Cell line | |
Background strain | C.B-17/Icr-scid/Jcl |
Appearance | |
Strain development | Developed by Kunie Matsuoka and Hiromichi Yonekawa, Tokyo Metropolitan Institute of Medical Science. The transgene was injected into the pronuclei of C.B-17/Icr-scid fertilized eggs. RBRC02767 (line 5), RBRC02768 (line 14), RBRC02769 (line 17), RBRC02770 (line 33), RBRC02771 ((scid background, the same line as the #70 in BBRC2013 article). |
Strain description | scid-INS-TRECK Transgenic mice, having the diphtheria toxin receptor (hDTR) driven by the human insulin promoter and Prkdc<scid> mutation. Hyperglycemia was observed within 3 days after the administration of DT. |
Colony maintenance | |
References | Biochem. Biophys. Res. Commun., 436, 400-405 (2013). 23747725 Transgenic Res., 21(1):51-62 (2011). 21431867 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Prkdcprotein kinase, DNA activated, catalytic polypeptide16Prkdc<scid>severe combined immunodeficiency Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter HBEGFheparin-binding EGF-like growth factor (human)UNHBEGFhuman Insulin promoter |
Ordering Information | |
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Donor DNA | Human Insulin promoter (SphI/BamHI) fragment, Rabbit Beta-globin intron, Human HB-EGF cDNA, Rabbit Beta-globin polyA/regulatory domain |
Research application | Diabetes and Obesity Research Immunology and Inflammation Research covid19_progression |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Biochem. Biophys. Res. Commun., 436, 400-405 (2013).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. The RECIPIENT of BIOLOGICAL RESOURCE, who belongs to a profit organization must obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Hiromichi Yonekawa (Tokyo Metropolitan Institute of Medical Science) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |