Strain Information | |
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Image | |
BRC No. | RBRC02846 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | 129S6/SvEvTac-Crx<tm1Clc> |
Former Common name | CRX K.O. |
H-2 Haplotype | |
ES Cell line | |
Background strain | 129S6/SvEvTac |
Appearance | light-bellied agouti [A<w>/A<w> B/B C/C] |
Strain development | Developed by Dr. Takahisa Furukawa, Harvard Medical School in 1999. |
Strain description | Crx gene knockout mice. Homozygous mutant mice lack a outer segment of retinal photoreceptor. |
Colony maintenance | Sibling x Sibling (Homozygote x Homozygote)Homozygous mutant mice are viable and fertile |
References | Nat. Genet., 23, 466-470 (1999). 10581037 |
Health Report | |
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Examination Date / Room / Rack | 2022/07/11Room:3-BRack:K 2022/06/13Room:3-BRack:K |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Crxcone-rod homeobox containig gene7Crx<tm1Clc>targeted mutation 1, Constance L Cepkocone-rod homeobox containg gene Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)7neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter) |
Ordering Information | |
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Donor DNA | mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, SV40 polyA, mouse Crx genomic DNA |
Research application | |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Genet., 23, 466-470 (1999). |
Depositor | Takahisa Furukawa (Osaka Bioscience Institute) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Iura Y, Udo H. Behavioral analyses of visually impaired Crx knockout mice revealed sensory compensation in exploratory activities on elevated platforms. Behav Brain Res 258 1-7(2014) 24140563 |