Strain Information | |
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Image | |
BRC No. | RBRC02900 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6;129P2-Poll<tm1Nmt> |
Former Common name | POLL KO mice, DNA polymerase lamda KO mouse |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | black [a/a B/B C/C] |
Strain development | Developed by Drs. Y. Kobayashi, K. Ikeda and N. Motoyama in National Institute for Longevity Sicences at 2000. |
Strain description | Poll, polymerase (DNA directed), lambda gene knock out mice. Homozygous mutant mice show hydrocephalus and a high rate of mortality after birth. The surviving males are sterile due to spermatozoal immobility. |
Colony maintenance | Heterozygote x Wild-type (C57BL/6JJcl) |
References | Mol. Cell. Biol., 22, 2769-2776 (2002). 11909969 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP19loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP19loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)19neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter) |
Ordering Information | |
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Donor DNA | Mouse PGK (phosphoglycerate kinase) promoter, Mouse PGK polyA (phosphoglycerate kinase gene terminater), E.coli Neomycin resistance gene, phage P1 loxP, Mouse polymerse (DNA directed), lambda genomic DNA |
Research application | |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Mol. Cell Biol., 22, 2769-2776 (2002).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Noboru Motoyama (National Center for Geriatrics and Gerontology) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |