Strain Information | |
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Image | |
BRC No. | RBRC03438 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6;129P2-Arx<tm1Kki>/6Rbrc |
Former Common name | Arx-6 KO |
H-2 Haplotype | |
ES Cell line | E14TG2a [129P2/OlaHsd] |
Background strain | |
Appearance | |
Strain development | Developed by Kunio Kitamura, Mitsubishi Kagaku Institute of Life Sciences. E14 ES cells were used to generate the mutant mice. |
Strain description | Arx gene knockout mice. A lacZ-neo cassette was inserted into the exon 2 of Arx gene. Hemizygous (-/Y) mutant males die within 12 hrs after birth. Main line: Arx-6 KO (RBRC03438). |
Colony maintenance | Heterozygote (female) x Wild-type (male)[C57BL/6JJcl] |
References | Nat Genet. 2002 32(3):359-69. 12379852 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter IRESinternal ribosomal entry site (EMCV)X Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter lacZbeta-galactosidase (E. coli)X Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)Xherpes simplex virus thymidine kinase promoter (HSV tk promoter) Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter SV40 polyA signalX |
Ordering Information | |
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Donor DNA | ARX genomic DNA (mouse), beta-galactosidase (E. coli), Neomycin resistance gene (E. coli), herpes simplex virus thymidine kinase promoter (HSV tk promoter), SV40 PolyA signal, Encephalomyocarditis virus (EMCV) internal ribosomal entry site (ires), STOP sequence |
Research application | Fluorescent Proteins/lacZ System Mouse Models for Human Disease |
Specific Term and Conditions | The BIOLOGICAL RESOURCE shall be used only for academic research purposes by a non-profit organization. The RECIPIENT of a non-profit organization must prior contact RIKEN BRC and negotiate with Mitsubishi Chemical Corporation to use the BIOLOGICAL RESOURCE for purposes of other than academic research. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE in relevant journals and meetings, the RECIPIENT must stipulate the source of the BIOLOGICAL RESOURCE and an acknowledgment to Mitsubishi Chemical Corporation. The RECIPIENT agrees that RIKEN BRC informs annually to Mitsubishi Chemical Corporation of RECIPIENT organization, RECIPIENT name, the specific research purpose and the date of distribution. |
Depositor | Kunio Kitamura (Mitsubishi Kasei Institute of Life Sciences) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovery and QC required prior to distribution |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |