Strain Information | |
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Image | |
BRC No. | RBRC04488 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | C.129P2(B6)-Sirpa<tm1Nog> |
Former Common name | SIRP alpha mutant mice |
H-2 Haplotype | |
ES Cell line | E14.1 [129P2/OlaHsd] |
Background strain | BALB/cAJcl |
Appearance | |
Strain development | Developed by Kenjiro Inagaki at Kobe University in 2000. A neomycin selection cassette replaced exons 7 and 8 of the M83 gene. The mutant mice were backcrossed C57BL/6N for 5 times, and then backcrossed to BALB/c over 15 times. |
Strain description | SHPS-1 (Ptpns1, protein tyrosine phosphatase, non-receptor type substrate 1) gene is a member of sinal-regulatory proteins, plays a impotant roles in integrin-mediated cytoskeletal reoganization, cell motility and the regulation of Rho. |
Colony maintenance | |
References | J. Biol. Chem., 277 (42) 39833-9 (2002). 12167615 EMBO J., 19, 6721-6731 (2000). 11118207 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Sirpasignal-regulatory protein alpha2Sirpa<tm1Nog>targeted mutation 1, Tetsuya NoguchiBit, CD172a, P84, SHPS-1, SIRP; Ptpns1;protein tyrosine phosphatase, non-receptor type substrate 1 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)2neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter) |
Ordering Information | |
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Donor DNA | mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, PGK PolyA, mouse Sirpa genomic DNA |
Research application | Immunology and Inflammation Research |
Specific Term and Conditions | The RECIPIENT f BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR. |
Depositor | Takashi Matozaki (Gunma University) |
Strain Status | Frozen sperm |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) |
Additional Info. | Genotyping protocol -PCR- Necessary documents for ordering:
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BRC mice in Publications |
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No Data |