Strain Information | |
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Image | |
BRC No. | RBRC04813 |
Type | Transgene |
Species | Mus musculus |
Strain name | B6.B6D2-Tg(Eno2-IREB2)1Kiwa |
Former Common name | NSE-IRP2 Tg |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Kazuhiro Iwai, Graduate School of Medicine, Osaka City University in 2002.Transgene was injected into the pronuclei of B6D2F1 fertilized eggs. Backcrossed to C57BL/6J. |
Strain description | This transgenic mice express a human IRP2 gene under the control of the rat neuron specific enolase promoter. IRP2 gene is a iron regulatory factor. Tg mice exhibit increased intercellular iron in neuron specific cells, and a nerve degeneration and behavior disorders with aging. |
Colony maintenance | Carrier X Noncarrier [C57BL/6J (Crlj)]Tg mice show a low activity after around 15 months of age, and a low motor coordination after around 21 months of age. |
References |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter IREB2iron responsive element binding protein 2 (human)UNIREB2rat NSE-promoter |
Ordering Information | |
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Donor DNA | Rat NSE-promoter, Human irp2, Human myc, Rabbit beta-globin intron, Rabbit 3' LTR |
Research application | Neurobiology Research |
Specific Term and Conditions | In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEVELOPER. RECIPIENT which wants to use the BIOLOGICAL RESOURCE for the purpose other than education or research in non-profit organization is requested to enter into a Material Transfer Agreement with Kyoto University. |
Depositor | Kazuhiro Iwai (Kyoto University) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |