Strain Information | |
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Image | |
BRC No. | RBRC04867 |
Type | Transgene |
Species | Mus musculus |
Strain name | C57BL/6-Tg(IGHEmu/VH-preMir125b-1)116Wakh |
Former Common name | B6-Emu-miRNA125 Tg#116 |
H-2 Haplotype | |
ES Cell line | |
Background strain | C57BL/6JJcl |
Appearance | |
Strain development | Developed by Takashi Sonoki, Department of Hematology and Oncology, Wakayama Medical University in 2009. The transgene was injected into the pronuclei of C57BL/6J fertilized eggs. The transgene was integrated into the chromosome 15 in the line 116, chromosome 6 in the line 005-I (005-1), and chromosome 5 in the line 005-II (005-2), respectively. Line 116 (RBRC04867), Line 005-I (RBRC04868), Line 005-II (RBRC04869). |
Strain description | These transgenic mice express a mouse microRNA129b-1 (precursor) under the control of the Human IGHEmu enhancer/mouse VH promoter. Tg mice exhibit IgM negative B-cell neoplasms, and die within 15-30 weeks of age in the line 116, 30-60 weeks of age in the line 005-I (005-1), and 30-45 weeks of age in the line 005-II (005-2), respectively. |
Colony maintenance | Carrier x Noncarrier [C57BL/6JJcl] |
References | Leukemia, 25(12):1849-56 (2011). 21738213 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Mir125b-1microRNA 125b-1UNMir125b-1human immunoglobulin heavy chain enhancer, mouse immunoglobulin heavy chain VH promoter |
Ordering Information | |
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Donor DNA | human immunoglobulin heavy chain endogenous enhancer (Emu), mouse immunoglobulin heavy chain VH promoter, Rat beta-globin genomic DNA, mouse Pre-miR125-b-1 genomic DNA |
Research application | Immunology and Inflammation Research |
Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Leukemia, 25(12):1849-56 (2011).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from use of the BIOLOGICAL RESOURCE. |
Depositor | Takashi Sonoki (Wakayama Medical University) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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