Strain Data Sheet

RBRC04908

Strain Information

Image
BRC No.RBRC04908
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6.C3B6-Tg(HIV NL4-3dPol)1607Yiw
Former Common nameB6-HIV/NL4-3dPol Tg#1607
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJmsSlc
Appearance
Strain developmentDeveloped by Yoichiro Iwakura, The Institute of Medical Science, The University of Tokyo in 1992. Transgene was injected into the pronuclei of B6C3F1 fertilized eggs. C57BL/6 background.
Strain descriptionTransgenic mice having a NL4-3 region of human immunodeficiency virus (HIV). C57BL/6 background. HIV gRNA (non-infectious) is produced in several organs. Tg mice show decreased body weight and cataract with aging.
Colony maintenance
ReferencesAIDS, 6, 1069-1075 (1992). 1466838

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
HIVHIV NL4-3UNHIV

Ordering Information

Donor DNA11.5 kb BglI-NcoI fragment derived from pNL4-3-2 (The fragment consists of the entire defective HIV proviral genome (9.4 kb: KpnI fragment deletion, nucleotide number 3826-4154)), the cellular franking sequence (2.0 kb), and the bacterial vector sequence (57 bp).)
Research applicationImmunology and Inflammation Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. AIDS, 6(10), 1069-1075 (1992).Please obtain the written consent from Professor Yoichiro Iwakura (iwakura@rs.tus.ac.jp; Research Institute for Biological Sciences, Tokyo University of Science) for the use.
DepositorYoichiro Iwakura (The University of Tokyo)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

No Data