Strain Information | |
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Image | |
BRC No. | RBRC05540 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.129-Brd1<tm1Hko> |
Former Common name | Brd1 KO, B6-Brd1 KO |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Atsushi Iwama, Graduate School of Medicine, Chiba University and Akihiko Koseki, RIKEN Research Center for Allergy and Immunology in 2005. The mutant mice were backcrossed to C57BL/6N. |
Strain description | Brd1 gene knockout mice. Exon 2 of Brd1 gene was replaced with a floxed neo cassette. Homozygous mutant mice show abnormal embryonic development including erythropoiesis (anemia), growth retardation, open neural tube and abnormal lens morphology, and die between E12.5 and E14.5. |
Colony maintenance | Heterozygote x Wild-type [C57BL/6NCrSlc] |
References | Blood, 118, 2443-2453 (2011). 21753189 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP15loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP15loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)15neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter) |
Ordering Information | |
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Donor DNA | E. coli Neomycin resistance gene, Mouse Phosphoglycerate kinase promoter (PGK promoter), SV40 PolyA signal, Bacteriophage loxP |
Research application | |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Blood, 118, 2443-2453 (2011). |
Depositor | Atsushi Iwama (Chiba University) |
Strain Status | Frozen sperm |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |