Strain Information | |
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Image | |
BRC No. | RBRC05552 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | 129S6.129S(Cg)-Grm6<tm1Nak> |
Former Common name | 129-mGluR6 KO, 129-Grm6 KO |
H-2 Haplotype | |
ES Cell line | CCE/EK.CCE [129S/SvEv-Gpi1<c>] |
Background strain | 129S6/SvEvTac |
Appearance | |
Strain development | Developed by Shigetada Nakanishi and Takahisa Furukawa, Osaka Bioscience Institute in 2012. The mutant mice were generated by backcrossing to 129S6/SvEvTac from B6-Grm6-lacZ Tg/Grm6 KO mice (RBRC01353). |
Strain description | mGluR6 (Grm6) knockout mice. 126 background. 1.2 kb sequence encoding part of the transmembrane region of Grm6 gene was replaced with a neomycin resistance cassette. |
Colony maintenance | Heterozygote x Homozygote [or Crossing to 129S6/SvEvTac] |
References | Cell, 80, 757-765 (1995). 7889569 J. Neurosci., 19, 2568-2579 (1999). 10087070 |
Health Report | |
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Examination Date / Room / Rack | 2022/05/31Room:4-CRack:L |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)11neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Ordering Information | |
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Donor DNA | E. coli Neomycin resistance gene, Herpes simplex virus thymidine kinase promoter (HSV tk promoter), Mouse Grm6 genomic DNA |
Research application | Neurobiology Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cell, 80, 757-765 (1995). J. Neurosci., 19, 2568-2579 (1999).Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must contract an MTA with the DEPOSITOR (Osaka University). |
Depositor | Drs. Shigetada Nakanishi and Takahisa Furukawa (Osaka Bioscience Institute) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Orlandi C, Omori Y, Wang Y, Cao Y, Ueno A, Roux MJ, Condomitti G, de Wit J, Kanagawa M, Furukawa T, Martemyanov KA. Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors. Cell Rep 25(1) 130-145.e5(2018) 30282023 |