Strain Information | |
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Image | |
BRC No. | RBRC05553 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.129P2-Pmaip1<tm1Ttg> |
Former Common name | B6-Noxa KO |
H-2 Haplotype | |
ES Cell line | E14.1 [129P2/OlaHsd] |
Background strain | C57BL/6JJcl |
Appearance | |
Strain development | Developed by Tsukasa Shibue and Tadatsugu Taniguchi, Graduate School of Medicine, University of Tokyo in 2003. E14.1 ES cell derived. The mutant mice were backcrossed to C57BL/6J. |
Strain description | Noxa (Pmaip1) gene knockout mice. A 2.4 kb genomic region including exons 1 and 2 of the Pmaip1 gene was replaced with a neomycin selection cassette. Homozygous mutant mice are resistant to X-ray irradiation-induced gastrointestinal death. |
Colony maintenance | Heterozygote x Wild-type [C57BL/6JJcl] |
References | Genes Dev., 17, 2233-2238 (2003). 12952892 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Pmaip1phorbol-12-myristate-13-acetate-induced protein 118Pmaip1<tm1Ttg>targeted mutation 1, Tadatsugu Taniguchi Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)18neo; neomycin; |
Ordering Information | |
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Donor DNA | E. coli Neomycin resistance gene |
Research application | |
Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT shall inform the DEPOSITOR about the purpose of the use of the BIOLOGICAL RESOURCE and shall limit the use within the scope of the purpose described in this Agreement. The RECIPIENT shall inform the DEPOSITOR about the results obtained by the use of the BIOLOGICAL RESOURCE. |
Depositor | Tadatsugu Taniguchi (The University of Tokyo) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |