Strain Data Sheet
RBRC05756
Strain Information | |
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| Image | |
| BRC No. | RBRC05756 |
| Type | Targeted Mutation |
| Species | Mus musculus |
| Strain name | B6.Cg-Spry2<tm1Ayos> |
| Former Common name | Sprouty2 KO, B6-Spry2 KO |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | |
| Appearance | |
| Strain development | Developed by Akihiko Yoshimura, Medical Institute of Bioregulation, Kyushu University. |
| Strain description | Sprouty2 (Spry2) gene knockout mice. Exon 2 was replaced with a PGK-neo cassette. Homozygous mutant mice exhibit enteric nerve hyperplasia. About half of homozygotes die within 6 weeks after birth. |
| Colony maintenance | Heterozygote x Wild-type [C57BL/6JJcl] |
| References | Nat. Neurosci., 8, 855-857 (2005). 15937482 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |
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| Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)14mouse phosphoglycerate kinase promoter (PGK promoter) |
Ordering Information | |
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| Donor DNA | Mouse Spry2 genomic DNA, Mouse Phosphoglycerate kinase promoter (PGK promoter), E. coli Neomycin resistance gene |
| Research application | Neurobiology Research |
| Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Neurosci., 8 ,855-857 (2005).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
| Depositor | Akihiko Yoshimura (Keio University) |
| Strain Status |  Frozen sperm |
| Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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| No Data |