Strain Information | |
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Image | |
BRC No. | RBRC05885 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.Cg-Vdr<tm1Ska> |
Former Common name | B6-Vdr KO |
H-2 Haplotype | |
ES Cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] |
Background strain | |
Appearance | |
Strain development | Developed by Dr. Shigeaki Kato, Institute of Molecular and Cellular Biosciences, University of Tokyo. C57BL/6 and CBA mixed. |
Strain description | Vitamin D receptor gene knockout mice. 1.1kb region containing exon 2 of Vdr was replaced with a neomycin resistance cassette. Homozygous mutant mice show vitamin D dependent rickets type II. |
Colony maintenance | Heterozygote x Wild-type |
References | Endocrinology, 141, 1317-1324 (2000). 10746634 Nat. Genet., 16, 391-396 (1997). 9241280 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)15neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter) |
Ordering Information | |
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Donor DNA | mouse phosphoglycerate kinase (PGK) genomic DNA, E. coli neo, mouse Vdr genomic DNA |
Research application | Developmental Biology Research Mouse Models for Human Disease |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Genet., 16, 391-396 (1997).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEVELOPER (Dr. Shigeaki Kato, uskato0525@gmail.com). |
Depositor | Kou-ichi Jishage (Chugai Pharmaceutical Co., Ltd.) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |