Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jun 20, 2018
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RBRC No. RBRC06153  
Type TransgeneCartagena  
Species Mus musculus  
Strain name B6.Cg-Tg(TOPGAL) Ctnnb1<Rgsc1880>  
Former Common name TOPGAL;Ctnnb1/C429S (B6), B6-TOPGAL Ctnnb1/C429S  
H-2 Haplotype No Data  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Takuya Murata and Yoichi Gondo, RIKEN BioResource center in 2012. C57BL/6J background.  
Strain description Ins-TOPGAL and Ctnnb1 C429S mutant mice. Ctnnb1 C429S mutant mice were generated by ENU mutagenesis. C492S homozygous mutant mice are infertile. Ins-TOPGAL transgenic mice are useful for visualizing Wnt signal pathway. The transgene contains the nLacZ gene under the control of a TOPFLASH promoter (6x TCF binding motifs upstream of a TK promoter). The transgene construct was flanked by the insulator core elements.  
Colony maintenance Tg: Carrier x Noncarrier [C57BL/6JJcl]; Ctnnb1: Heterozygote x Wild-type [C57BL/6JJcl]  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol nls  
Symbol name SV40 large T antigen nuclear localization signal (NLS)  
Chromosome UN  
Common name No Data  
Symbol description No Data  
Promoter TOPFLUSH promoter  
 2 Symbol lacZ  
Symbol name beta-galactosidase (E. coli)  
Chromosome UN  
Common name No Data  
Symbol description No Data  
References Nat Rev Genet. 2008 Oct;9(10):803-10.
  
Trends in large-scale mouse mutagenesis: from genetics to functional genomics.
Trends in large-scale mouse mutagenesis: from genetics to functional genomics.
Research applications No Data  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
後日指定。(will be announced).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.  
Additional information
 1 Mouse of the Month Nov 2014  
Depositor Gondo, Yoichi (RIKEN, BioResource Center)  Gondo, Yoichi 
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