Strain Information | |
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Image | |
BRC No. | RBRC06160 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | C57BL/6N-Slc5a10<tm1Csk> |
Former Common name | SGLT5 knockout mouse, SGLT5 KO, B6-Slc5a10 KO |
H-2 Haplotype | |
ES Cell line | |
Background strain | C57BL/6NCrlCrlj |
Appearance | |
Strain development | Developed by Chugai Pharmaceutical Co., Ltd. ES cells derived from C57BL/6N were used to disrupt the Slc5a10 gene by homologous recombination. C57BL/6N background. |
Strain description | Slc5a10 (SGLT5) gene knockout mice. Part of exon 3 through part of 6 was replaced with a PGK-neo cassette. Homozygous mutant mice exhibit abnormal renal reabsorption (increased urinary fructose and mannose excretion). Fatty liver is also observed in mice fed a high fructose diet. Viable and fertile. |
Colony maintenance | Homozygote x Homozygote [or Crossing to C57BL/6NCrlCrlj] |
References | PLoS One. 2013;8(2):e56681. 23451068 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Slc5a10solute carrier family 5 (sodium/glucose cotransporter), member 1011Slc5a10<tm1Csk>targeted mutation 1, Chugai Pharmaceutical Co., Ltd. Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)11mouse Phosphoglycerate kinase promoter (PGK promoter), phage T7 gb2 promoter |
Ordering Information | |
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Donor DNA | マウス Phosphoglycerate kinase-1遺伝子プロモーター, phage T7 gb2遺伝子プロモーター, 大腸菌 ネオマイシン耐性遺伝子 cDNA, 合成核酸 ポリA付加シグナル |
Research application | Metabolism Research |
Specific Term and Conditions | The RECIPIENT of the BIOLOGICAL RESOURCE is requested to make a Material Transfer Agreement specified by the DEPOSITOR. (Contact info: Mr. Taku Fukuzawa <fukuzawatk@chugai-pharm.co.jp>, Discovery Pharmacology Dept.) |
Depositor | Kou-ichi Jishage (Chugai Pharmaceutical Co., Ltd.) |
Strain Status | Frozen sperm |
Strain Availability | Recovery and QC required prior to distribution |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |