Strain Information | |
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Image | |
BRC No. | RBRC06393 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6;129P2-Fbxw7<tm1Kei> |
Former Common name | |
H-2 Haplotype | |
ES Cell line | E14 [129P2/OlaHsd] |
Background strain | |
Appearance | |
Strain development | Developed by Keiichi Nakayama, Medical Institute of Bioregulation, Kyushu University. E14 ES cells were used. The mutant mice were crossed to C57BL/6J over 6 times. |
Strain description | Fbxw7 gene floxed mice. Exon 5 was falnked by loxP sites. |
Colony maintenance | Homozygote x Homozygote [or Crossing to C57BL/6JJcl] |
References | J Exp Med., 204, 2875-2888 (2007). 17984302 The Journal of Clinical Investigation, 121, 342-354 (2010). 21123947 Genes & Dev., 22, 986-991 (2008). 18367647 Cancer Cell, 23, 347-361 (2013). 23518349 J. Biol. Chem., 286, 13754-13764 (2011). 21349854 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP3loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP3loxP |
Ordering Information | |
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Donor DNA | Bacteriophage P1 LoxP sites, mouse Fbxw7 genomic DNA |
Research application | Cancer Research Cell Biology Research Cre/loxP system Hematological Research Metabolism Research Reproductive Biology Research |
Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR. |
Depositor | Keiichi Nakayama (Kyushu University) |
Strain Status | Frozen sperm |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- Mouse of the Month Jan 2015 |
BRC mice in Publications |
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