Strain Data Sheet

RBRC06408

Strain Information

Image
BRC No.RBRC06408
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC;129(B6)-Siglec1<tm1(HBEGF)Mtka>
Former Common nameCD169-DTR, BALB-Siglec1/DTR KI
H-2 Haplotype
ES Cell lineR1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]
Background strain
Appearance
Strain developmentDeveloped by Masato Tanaka, RIKEN Research Center for Allergy and Immunology. R1 ES cells were used. The mutant mice were crossed to BALB/c over 5 times.
Strain descriptionCD169 (Siglec1) DTR knock-in mice. HB-EGF is expressed from CD169 locus.
Colony maintenanceHomozygote x Homozygote [or Crossing to BALB/cAJcl]
ReferencesNat. Biotechnol., 19, 746-750 (2001). 11479567
J. Clin. Invest., 117, 2268-2278 (2007). 17657313

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin2Siglec1<tm1(HBEGF)Mtka>targeted mutation 1, Masato Tanaka

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
HBEGFheparin-binding EGF-like growth factor (human)2HBEGF

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP2loxP

Ordering Information

Donor DNAHuman HB-EGF(DTR) cDNA, Phage P1 loxP site, Mouse Siglec1 genomic DNA
Research applicationCre/loxP system
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Biotechnol., 19, 746-750 (2001). J. Clin Invest., 117, 2268-2278 (2007).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR/DEVELOPER (Masato Tanaka, Ph.D. and Kenji Kohno, Ph.D.) is requested.
DepositorMasato Tanaka (Tokyo University of Pharmacy and Life Sciences)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data