Strain Information | |
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Image | |
BRC No. | RBRC06408 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | C;129(B6)-Siglec1<tm1(HBEGF)Mtka> |
Former Common name | CD169-DTR, BALB-Siglec1/DTR KI |
H-2 Haplotype | |
ES Cell line | R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>] |
Background strain | |
Appearance | |
Strain development | Developed by Masato Tanaka, RIKEN Research Center for Allergy and Immunology. R1 ES cells were used. The mutant mice were crossed to BALB/c over 5 times. |
Strain description | CD169 (Siglec1) DTR knock-in mice. HB-EGF is expressed from CD169 locus. |
Colony maintenance | Homozygote x Homozygote [or Crossing to BALB/cAJcl] |
References | Nat. Biotechnol., 19, 746-750 (2001). 11479567 J. Clin. Invest., 117, 2268-2278 (2007). 17657313 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin2Siglec1<tm1(HBEGF)Mtka>targeted mutation 1, Masato Tanaka Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter HBEGFheparin-binding EGF-like growth factor (human)2HBEGF Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP2loxP |
Ordering Information | |
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Donor DNA | Human HB-EGF(DTR) cDNA, Phage P1 loxP site, Mouse Siglec1 genomic DNA |
Research application | Cre/loxP system |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Biotechnol., 19, 746-750 (2001). J. Clin Invest., 117, 2268-2278 (2007).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR/DEVELOPER (Masato Tanaka, Ph.D. and Kenji Kohno, Ph.D.) is requested. |
Depositor | Masato Tanaka (Tokyo University of Pharmacy and Life Sciences) |
Strain Status | Frozen embryos |
Strain Availability | Recovery and QC required prior to distribution |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |