Strain Data Sheet
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Data update: Oct 24, 2018
Health Report   PCR Protocol   Thawing Method
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RBRC No. RBRC09758  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6;129P2-Chd8<tm1Kei>  
Former Common name Chd8/Duplin KO  
H-2 Haplotype No Data  
ES cell line E14 [129P2/OlaHsd]  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Deposited by Keiichi Nakayama, Medical Institute of Bioregulation, Kyusyu University in 2016. E14(129P2/OlaHsd) ES cell line was used. Mixed genetic background in C57BL/6 and 129P2.  
Strain description Chd8 (chromodomain helicase DNA binding protein 8) knockout mice. Homozygous mutants are lethal. Heterozygous mutant displays autistic like behavior. All exons were replaced by loxP-neo cassette. Mouse strain carrying deletion of only long isoform of Chd8 (Chd8l) is available as RBRC09759.  
Health Report
Gene Details
Promoter No Data  
 1 Symbol No Data  
Symbol name SV40 PolyA signal  
Chromosome 14  
Common name No Data  
Symbol description No Data  
 2 Symbol Chd8  
Symbol name chromodomain helicase DNA binding protein 8  
Chromosome 14  
Common name No Data  
Symbol description No Data  
 3 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 14  
Common name No Data  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 4 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 14  
Common name No Data  
Symbol description No Data  
References No Data  
Research applications Cre/loxP system,
Mouse Models for Human Disease  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Nakayama, Keiichi (Medical institute of bioregulation, Kyushu University)  Nakayama, Keiichi 
Strain Status /
Availability
(Expected delivery)

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