Strain Information | |
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Image | |
BRC No. | RBRC10053 |
Type | Targeted Mutation Congenic |
Species | Mus musculus |
Strain name | B6(Cg)-Aqp4<tm1.1Tsna> |
Former Common name | AQP4 KO, Aqp4- |
H-2 Haplotype | |
ES Cell line | RENKA [C57BL/6NCrlCrlj] |
Background strain | |
Appearance | |
Strain development | Developed by Mika Tsujita, Brain Research Institute, Niigata University. RENKA ES cells derived from C57BL/6 were used to generate a strain (RBRC10054) harboring a floxed Aqp4 allele with the neo resistance gene. By crossing with a TLCN Cre mouse strain, exon 2, 3 and neo were deleted. C57BL/6 genetic background. |
Strain description | Aqp4 (aquaporin 4) knockout mice. |
Colony maintenance | |
References | Neurosci. Res., 64, 208-212 (2009). 19428702 |
Health Report | |
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Examination Date / Room / Rack | 2024/01/22Room:3-CRack:G 2023/10/23Room:3-CRack:G 2023/07/24Room:3-CRack:G 2023/04/24Room:3-CRack:G 2023/01/23Room:3-CRack:G 2022/10/25Room:3-CRack:G 2022/07/25Room:3-CRack:G 2022/04/25Room:3-CRack:G |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP18loxP |
Ordering Information | |
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Donor DNA | Phage P1 loxP site, mouse Aqp4 genomic DNA |
Research application | Cre/loxP system Neurobiology Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Neurosci. Res., 64, 208-212 (2009). |
Depositor | Mika Terumitsu-Tsujita (Niigata University) |
Strain Status | Live mice Frozen embryos Frozen sperm |
Strain Availability | Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) Live mouse (1 to 3 months) |
Additional Info. | Mouse of the Month Sep 2017 Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Serizawa K, Miyake S, Katsura Y, Yorozu K, Kurasawa M, Tomizawa-Shinohara H, Yasuno H, Matsumoto Y. Intradermal AQP4 peptide immunization induces clinical features of neuromyelitis optica spectrum disorder in mice. J Neuroimmunol 380 578109(2023) 37210799 |