Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Apr 20, 2018
Health Report   PCR Protocol   Thawing Method
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  Mouse Marking
Figure
  Order
RBRC No. RBRC-GSC0080  
Type Chemically-induced Mutation   wks
Species Mus musculus  
Strain name M100451  
Former Common name No Data  
H-2 Haplotype No Data  
Background strain No Data  
Appearance
 1 Appearance severe brachypodism, ankylosis of the knee joint, and malformation with early-onset OA of the elbow joint  
Genotype homozygotes  
 2 Appearance brachypodism and ankylosis  
Genotype heterozygotes  
Strain description This mutant strain carries an allele of Gdf5 gene, Gdf5<Rgsc451>,
which causes an amino acid substitution (W408R) in a highly conserved
region of the active signaling domain of the GDF5 protein.  
Health Report
Gene Details
Promoter   
 1 Symbol Gdf5  
Symbol name growth differentiation factor 5  
Chromosome No Data  
Common name bp, cartilage-derived morphogenetic protein-1, CDMP-1  
Symbol description No Data  
References Hum Mol Genet. 2007 Oct 1;16(19):2366-75. Epub 2007 Jul 26.  

Research applications Mouse Models for Human Disease  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of for-profit institution must contact the DEPOSITOR separately.
The RECIPIENT of not for-profit institution must contact and discuss in good faith with the DEPOSITOR regarding inventorship, ownership, patent filing and licese fees and others, prior to filing a patent or make a contract with license fees with a third party for invention or products obtained from research results by using the BIOLOGICAL RESOURCES.  
Additional information
 1 Mouse of the Month Sep 2007  
 2 Genotyping protocol <PCR>  
Depositor RIKEN Genomic Sciences Center   
Strain Status /
Availability
(Expected delivery)

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