Strain Data Sheet
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Data update: May 23, 2017
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RBRC No. RBRC00762  
Type Spontaneous Mutation   4wks
Species Mus musculus  
Strain name C;B6-a/a-b/b-WSh/WSh  
Former Common name W Sash Brown  
H-2 Haplotype No Data  
Background strain No Data  
Appearance
 1 Appearance white coat with black eyes  
Genotype a/a b/b C/C sh/sh  
Strain development C57BL/6-Kit<W-sh> mice were deposited by Dr. Yukihiko Kitamuta, Osaka University to the RIKEN BRC. The mice were backcrossed to BALB/c for several generation, then maintained by sister-brother mating as homozygous state.  
Strain description The Kit<W-sh> mutation arose spontaneously in the (C3H/HeN x 101/H)F1 at the MRC (Lyon et al., 1982). Homozygous mice are white coat with black eyes. Heterozygotes are black with a white sash. This strain is useful for study of melanogenesis and neural crest migration.  
Colony maintenance Sibling mating (Homozygote x Homozygote)
Homozygous mutant mice are viable and fertile.  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Kit  
Symbol name kit oncogene  
Chromosome 5  
Common name No Data  
Symbol description No Data  
References Am J Pathol. 2005 Sep;167(3):835-48.
Blood. 1992 Sep 15;80(6):1448-53.
Blood. 1994 Jun 15;83(12):3509-16.
Blood. 1999 Oct 15;94(8):2658-66.
Development. 1993 Jul;118(3):705-17.  
Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
Research applications Reproductive Biology Research  
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)  
Additional information
 1 Genetic Background  
 2 Genotyping protocol <PCR>  
Depositor RIKEN, BioResource Center   
Strain Status /
Availability
(Expected delivery)

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