Strain Data Sheet
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Data update: May 23, 2017
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RBRC No. RBRC00858  
Type Targeted MutationCartagena   wks
Species Mus musculus  
Strain name B6;129S6-Bcl2l12/Irf3<tm1Ttg>/TtgRbrc  
Former Common name IRF-3 KO/B6; IRF-3 Knockout mice, C57BL/6J  
H-2 Haplotype No Data  
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]  
Donor strain 129S6/SvEv via CCE ES cell line  
Background strain C57BL/6J Jcl  
Appearance
 1 Appearance black  
Genotype No Data  
Strain development Developed by Tadatsugu Taniguchi, Graduate School of Medicine and Faculty of Medicine, University of Tokyo. C57BL/6 semicongenic strain.  
Strain description The Irf3 deficient mice were created by replacing a 2.2 kb region of Irf3 containing a putative transcription initiation site and the coding N-terminal region of the DNA binding domain. The analysis of MEFs demonstrated loss of Irf3 protein. Homozygous null mice are more susceptible to viral infection such as encephalomyocarditis virus and exhibit lower serum interferon levels in response to viral infection, indicating incapability of the mutant to respond against viral infection.  
Colony maintenance Homozygote x Homozygote  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Bcl2l12  
Symbol name BCL2-like 12 (proline rich)  
Chromosome 7  
Common name Bcl2-L12, Bcl-L12  
Symbol description No Data  
 2 Symbol Irf3  
Symbol name interferon regulatory factor 3  
Chromosome 7  
Common name C920001K05Rik, IRF-3  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 3 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 7  
Common name neo; neomycin;  
Symbol description No Data  
References Immunity. 2000 Oct;13(4):539-48.  



Research applications Immunology and Inflammation Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT shall inform the DEPOSITOR about the purpose of the use of the BIOLOGICAL RESOURCE and shall limit the use within the scope of the purpose described in this Agreement. The RECIPIENT shall inform the DEPOSITOR about the results obtained by the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 Taniguchi Lab HP  
 2 Mouse of the Month May 2005
Genetic Background  
 3 Genotyping protocol <PCR>  
Depositor Taniguchi, Tadatsugu (The University of Tokyo, Graduate School of Medicine)  Taniguchi, Tadatsugu 
Strain Status /
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